• CONTACT INFORMATION

Address: University of Oxford, Department of Physiology, Anatomy and Genetics,

Sleep and Circadian Neuroscience Institute (SCNi),

Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE

Phone: +44 (0) 1865 618676 (office), +44 (0) 7557 372024 (mobile)

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Web page: https://www.dpag.ox.ac.uk/team/vladyslav-vyazovskiy

 

  • EDUCATION

2004                      PhD, University of Zurich, Zurich, Switzerland     

1997                      MSc, University of Kharkov, Kharkov, Ukraine

                                   

  • CURRENT POSITION

2013 –                                   Senior Research Fellow, Associate Professor of Neuroscience

                                Department of Physiology, Anatomy and Genetics (DPAG), University of Oxford

                                                                                                                                    

  • PREVIOUS POSITIONS

2012-2013            Lecturer in Sleep and Chronobiology

                                Department of Biochemistry and Physiology, University of Surrey, UK;

2011-2012            Associate Scientist

Department of Psychiatry, University of Wisconsin-Madison, Madison, USA;

2008-2011            Assistant Scientist

Department of Psychiatry, University of Wisconsin-Madison, Madison, USA;

2005-2008            Research Associate

Department of Psychiatry, University of Wisconsin-Madison, Madison, USA

 

  • ADMINISTRATIVE DUTIES

2015-                     Senior Doctoral Training Advisor, DPAG, University of Oxford

2016-                     Wellcome MSc/DPhil Programme in Neuroscience, Module co-organiser

2018-                     Board of Examiners, Biomedical Sciences, University of Oxford

2016-2018            Exam Board member, Online Programme in Sleep Medicine, University of Oxford

 

  • TEACHING

2014-                     2nd year Medical Sciences / Biomedical Sciences; FHS Cell & Systems Biology, Medical Sciences & Neuroscience;

2015-2016            Course ‘Cognition and Culture’, Human Sciences;

2016-                     Module "Genes, Circuits and Behaviour", MSc in Neuroscience;

2016-                     The Oxford Online Programme in Sleep Medicine;

2016-                     Oxford Doctoral Training Centre;                                             

2016-                     Biomedical Sciences Year 2 (FHS Part I): Sleep and Circadian Neuroscience Option

2014-                     DPhil transfer/ status confirmation examinations, DPhil vivas, FHS of Medical Sciences extended essay advisor;

2015-2017            ‘Sleep and Circadian Neuroscience’ Summer School, University of Oxford;

2017                       European Sleep Research Society Sleep Science School "Neural Networks in Sleep"

 

  • KEYNOTE LECTURES, FELLOWSHIPS AND AWARDS

2016                       Keynote speaker, 1st International Conference on Sleep Spindles, Budapest, Hungary;

2015                       Keynote speaker, 12th Annual Symposium of Korean Sleep Research Society (KSSR);

2014                       Travel Awardee for the 2014 American College of Neuropsychopharmacology meeting;

2013                   Keynote speaker, XIV Brazilian Sleep Meeting, Rio de Janeiro, Brazil;

2013                       “Year in Review”, Invited speaker, 25th Meeting of British Sleep Society, UK;

2011                       “Notable Publication in Sleep”, Sleep Research Society, 2011;

2008                       Sleep Research Society Young Investigator Award;

2005-2006         Two-years Research Fellowship, Swiss National Science Foundation;

2002                       Travel Awardee for the 2002 FENS meeting, Paris

 

  • EDITORIAL ACTIVITIES
  1. SLEEP magazine (Editorial Board member)
  2. Journal of Sleep Research (Associate Editor)
  3. PLoS1 (Academic Editor)
  4. Journal of Nature and Science of Sleep (Consulting Editor)
  5. Frontiers in Systems Neuroscience (Associate Editor)
  6. Sleep and Vigilance (Editorial Board member)
  7. Sleep Spindles & Cortical UP states (Editorial Board member)

 

  • PROFESSIONAL ACTIVITIES

2014-present          Member of Topical Team ‘Hibernation and Torpor’, European Space Agency;

2018-present          Member of Scientific Committee, European Sleep Research Society

 

  • FUNDING (current)

Project Title

Funding source

Amount

Period

Role

Local sleep homeostasis and single cell rest

MRC project grant

£945,072

2019-2022

PI

Fasting-induced torpor in mice: effects on sleep and behaviour

NC3Rs studentship

£90,000

2019-2022

Supervisor

Investigating the relationship between glucose homeostasis and torpor in mice

Novo-Nordisk - Oxford Fellowship

£205,109

2018-2021

PI

Investigating metabolic control and sleep during photoperiod-induced torpor in Djungarian hamsters (Phodopus sungorus)

Novo-Nordisk - Oxford Fellowship

£248,522

2018-2021

PI

Elucidating torpor's effects on brain activity and behaviour and investigating its neuroprotective properties against acute ischaemic stroke

MRC Clinical Research Training Fellowship

£279,828

2018-2021

Supervisor

 

Neural signatures of tinnitus across the sleep-wake cycle

Action on Hearing Loss studentship

£85,813

2018-2021

Co-supervisor

 

  • RESEARCH GROUP

postdoctoral researchers:

Dr Tomoko Yamagata, Dr Laura McKillop, Dr Vincent Van der Vinne

 

DPhil students:

1st supervisor: Christopher Thomas, Lukas Krone, Cristina Blanco Duque

2nd supervisor: Martin Kahn, Angus Fisk, Minas Salib, Alberto Lazari, Linus Milinski, Raffaele Sarnataro, Christian Harding

Completed: Ross Purple (2017), Mathilde Guillaumin (2018), Nanyi Cui (2018), Laura McKillop (2018)

 

other:

  1. Dr Yige Huang (MRC CRTF, 2018-2021): primary supervisor;
  2. Dr Hannah Alfonsa (Sir Henry Wellcome Postdoctoral Fellow, 2017-2019): research sponsor
  3. Kathleen Reinhardt (Oxford Brookes University, visiting student)
  4. Benjamin Breant (University of Sorbonne, visiting student)
  5. Sarah Flahery (Research placement student)
  6. Chiara McDermott (FHS project student)

 

PUBLICATIONS (total 68, h-index 27: Web of Science)

 

  1. McKillop, L. M., and Vyazovskiy, V. V. (2018) Sleep- and Wake-Like States in Small Networks In Vivo and In Vitro. Handb Exp Pharmacol, in press
  2. McKillop, L. E., Fisher, S. P., Cui, N., Peirson, S. N., Foster, R. G., Wafford, K. A., and Vyazovskiy, V. V. (2018) Effects of ageing on cortical neural dynamics and local sleep homeostasis in mice. J Neurosci 38, 3911-3928
  3. Hasan, S., Foster, R. G., Vyazovskiy, V. V., and Peirson, S. N. (2018) Effects of circadian misalignment on sleep in mice. Sci Rep 8, 15343
  4. Guillaumin, M. C. C., McKillop, L. E., Cui, N., Fisher, S. P., Foster, R. G., de Vos, M., Peirson, S. N., Achermann, P., and Vyazovskiy, V. V. (2018) Cortical region-specific sleep homeostasis in mice: effects of time of day and waking experience Sleep 41, 7
  5. Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., and Peirson, S. N. (2018) Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal. Front Neurol 9
  6. Ang, G., McKillop, L. E., Purple, R. J., Blanco Duque, C., Peirson, S. N., Foster, R. G., Harrison, P. J., Sprengel, R., Davies, K. E., Oliver, P. L., Bannerman, D. M., and Vyazovskiy, V. V. (2018) Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders. Transl Psychiatry 8, 154
  7. Vyazovskiy, V. V., Walton, M. E., Peirson, S. N., and Bannerman, D. M. (2017) Sleep homeostasis, habits and habituation. Curr Opin Neurobiol 44, 202-211
  8. Vyazovskiy, V. V., Palchykova, S., Achermann, P., Tobler, I., and Deboer, T. (2017) Different Effects of Sleep Deprivation and Torpor on EEG Slow-Wave Characteristics in Djungarian Hamsters. Cereb Cortex 7, 1-12
  9. Tam, S. K., Hasan, S., Choi, H. M. C., Brown, L. A., Jagannath, A., Hughes, S., Hankins, M. W., Foster, R. G., Vyazovskiy, V. V., Bannerman, D. M., and Peirson, S. N. (2017) Constant light desynchronises olfactory versus object and visuospatial recognition memory performance. J Neurosci, 3213-3216
  10. Panagiotou, M., Vyazovskiy, V. V., Meijer, J. H., and Deboer, T. (2017) Differences in electroencephalographic non-rapid-eye movement sleep slow-wave characteristics in aged mice between young and old mice. Sci Rep, 43656
  11. Meisel, C., Klaus, A., Vyazovskiy, V. V., and Plenz, D. (2017) The interplay between long- and short-range temporal correlations shapes cortex dynamics across vigilance states. J Neurosci 37, 10114-10124
  12. Sela, Y., Vyazovskiy, V. V., Cirelli, C., Tononi, G., and Nir, Y. (2016) Responses in Rat Core Auditory Cortex are Preserved during Sleep Spindle Oscillations. Sleep 39, 1069-1082
  13. Rodriguez, A. V., Funk, C. M., Vyazovskiy, V. V., Nir, Y., Tononi, G., and Cirelli, C. (2016) Why Does Sleep Slow-Wave Activity Increase After Extended Wake? Assessing the Effects of Increased Cortical Firing During Wake and Sleep. J Neurosci 36, 12436-12447
  14. Pilorz, V., Tam, S. K., Hughes, S., Pothecary, C. A., Jagannath, A., Hankins, M. W., Bannerman, D. M., Lightman, S. L., Vyazovskiy, V. V., Nolan, P. M., Foster, R. G., and Peirson, S. N. (2016) Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light. PLoS Biol 14, e1002482
  15. Gagliano, M., Vyazovskiy, V. V., Borbely, A. A., Grimonprez, M., and Depczynski, M. (2016) Learning by Association in Plants. Sci Rep 6, 38427
  16. Fisher, S. P., Cui, N., McKillop, L. E., Gemignani, J., Bannerman, D. M., Oliver, P. L., Peirson, S. N., and Vyazovskiy, V. V. (2016) Stereotypic wheel running decreases cortical activity in mice. Nat Commun 7, 13138
  17. Boccio, M., Fisher, S. P., Unal, G., Ellender, T. J., Vyazovskiy, V. V., and Capogna, M. (2016) Modulation of paracapsular nitric oxide synthase expressing neurons of the amygdala by sleep and serotonin. eNeuro 3
  18. Vyazovskiy, V. V., and Faraguna, U. (2015) Sleep and synaptic homeostasis. Curr Top Behav Neurosci 25, 91-121
  19. Vyazovskiy, V. V. (2015) Neuroscience. Mapping the birth of the sleep connectome. Science 350, 909-910
  20. Vyazovskiy, V. V. (2015) Sleep, recovery, and metaregulation: explaining the benefits of sleep. Nat Sci Sleep 7, 171-184
  21. Nir, Y., Vyazovskiy, V. V., Cirelli, C., Banks, M. I., and Tononi, G. (2015) Auditory responses and stimulus-specific adaptation in rat auditory cortex are preserved across NREM and REM sleep. Cereb Cortex 25, 1362-1378
  22. Axelsson, J., and Vyazovskiy, V. V. (2015) Banking Sleep and Biological Sleep Need. Sleep 38, 1843-1845
  23. Abasolo, D., Simons, S., Morgado da Silva, R., Tononi, G., and Vyazovskiy, V. V. (2015) Lempel-Ziv complexity of cortical activity during sleep and waking in rats. J Neurophysiol 113, 2742-2752
  24. Vyazovskiy, V. V., and Foster, R. G. (2014) Sleep: a biological stimulus from our nearest celestial neighbor? Curr Biol 24, R557-560
  25. Vyazovskiy, V. V., and Delogu, A. (2014) NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness. Neuroscientist 20, 203-219
  26. Vyazovskiy, V. V., Cui, N., Rodriguez, A. V., Funk, C., Cirelli, C., and Tononi, G. (2014) The dynamics of cortical neuronal activity in the first minutes after spontaneous awakening in rats and mice. Sleep 37, 1337-1347
  27. Fisher, S. P., and Vyazovskiy, V. V. (2014) Local sleep taking care of high-maintenance cortical circuits under sleep restriction. Sleep 37, 1727-1730
  28. Cui, N., McKillop, L. E., Fisher, S. P., Oliver, P. L., and Vyazovskiy, V. V. (2014) Long-term history and immediate preceding state affect EEG slow wave characteristics at NREM sleep onset in C57BL/6 mice. Arch Ital Biol 152, 156-168
  29. Vyazovskiy, V. V., Olcese, U., Cirelli, C., and Tononi, G. (2013) Prolonged wakefulness alters neuronal responsiveness to local electrical stimulation of the neocortex in awake rats. J Sleep Res 22, 264-271
  30. Vyazovskiy, V. V., and Harris, K. D. (2013) Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 14, 443-451
  31. Vyazovskiy, V. V. (2013) Cortical neuronal mechanisms of sleep homeostasis. Zh Vyssh Nerv Deiat Im I P Pavlova 63, 13-23
  32. Vyazovskiy, V. V., and Tobler, I. (2012) The temporal structure of behaviour and sleep homeostasis. PLoS One 7, e50677
  33. Bellesi, M., Vyazovskiy, V. V., Tononi, G., Cirelli, C., and Conti, F. (2012) Reduction of EEG theta power and changes in motor activity in rats treated with ceftriaxone. PLoS One 7, e34139
  34. Vyazovskiy, V. V., Olcese, U., Hanlon, E. C., Nir, Y., Cirelli, C., and Tononi, G. (2011) Local sleep in awake rats. Nature 472, 443-447
  35. Vyazovskiy, V. V., Cirelli, C., and Tononi, G. (2011) Electrophysiological correlates of sleep homeostasis in freely behaving rats. Prog Brain Res 193, 17-38
  36. Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., and Tononi, G. (2011) Regional slow waves and spindles in human sleep. Neuron 70, 153-169
  37. Hanlon, E. C., Vyazovskiy, V. V., Faraguna, U., Tononi, G., and Cirelli, C. (2011) Synaptic potentiation and sleep need: clues from molecular and electrophysiological studies. Curr Top Med Chem 11, 2472-2482
  38. Leemburg, S., Vyazovskiy, V. V., Olcese, U., Bassetti, C. L., Tononi, G., and Cirelli, C. (2010) Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 107, 15939-15944
  39. Faraguna, U., Nelson, A., Vyazovskiy, V. V., Cirelli, C., and Tononi, G. (2010) Unilateral cortical spreading depression affects sleep need and induces molecular and electrophysiological signs of synaptic potentiation in vivo. Cereb Cortex 20, 2939-2947
  40. Vyazovskiy, V. V., Tobler, I., Cirelli, C., and Tononi, G. (2009) Author's reply to "cerebral metabolism and sleep homeostasis: a comment on Vyazovskiy et al.". Brain Res Bull 80, 443-445
  41. Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., and Tononi, G. (2009) Cortical firing and sleep homeostasis. Neuron 63, 865-878
  42. Vyazovskiy, V. V., Faraguna, U., Cirelli, C., and Tononi, G. (2009) Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep/wake history and background activity. J Neurophysiol 101, 1921-1931
  43. Hanlon, E. C., Faraguna, U., Vyazovskiy, V. V., Tononi, G., and Cirelli, C. (2009) Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat. Sleep 32, 719-729
  44. Dash, M. B., Douglas, C. L., Vyazovskiy, V. V., Cirelli, C., and Tononi, G. (2009) Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. J Neurosci 29, 620-629
  45. Winsky-Sommerer, R., Knapman, A., Fedele, D. E., Schofield, C. M., Vyazovskiy, V. V., Rudolph, U., Huguenard, J. R., Fritschy, J. M., and Tobler, I. (2008) Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience 154, 595-605
  46. Vyazovskiy, V. V., and Tobler, I. (2008) Handedness leads to interhemispheric EEG asymmetry during sleep in the rat. J Neurophysiol 99, 969-975
  47. Vyazovskiy, V. V., Cirelli, C., Tononi, G., and Tobler, I. (2008) Cortical metabolic rates as measured by 2-deoxyglucose-uptake are increased after waking and decreased after sleep in mice. Brain Res Bull 75, 591-597
  48. Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., and Tononi, G. (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 11, 200-208
  49. Jones, S. G., Vyazovskiy, V. V., Cirelli, C., Tononi, G., and Benca, R. M. (2008) Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii). BMC Neurosci 9, 47
  50. Faraguna, U., Vyazovskiy, V. V., Nelson, A. B., Tononi, G., and Cirelli, C. (2008) A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci 28, 4088-4095
  51. Winsky-Sommerer, R., Vyazovskiy, V. V., Homanics, G. E., and Tobler, I. (2007) The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. Eur J Neurosci 25, 1893-1899
  52. Vyazovskiy, V. V., Tobler, I., and Winsky-Sommerer, R. (2007) Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization. Neuroscience 147, 833-841
  53. Vyazovskiy, V. V., Riedner, B. A., Cirelli, C., and Tononi, G. (2007) Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat. Sleep 30, 1631-1642
  54. Vyazovskiy, V. V., Achermann, P., and Tobler, I. (2007) Sleep homeostasis in the rat in the light and dark period. Brain Res Bull 74, 37-44
  55. Riedner, B. A., Vyazovskiy, V. V., Huber, R., Massimini, M., Esser, S., Murphy, M., and Tononi, G. (2007) Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 30, 1643-1657
  56. Douglas, C. L., Vyazovskiy, V., Southard, T., Chiu, S. Y., Messing, A., Tononi, G., and Cirelli, C. (2007) Sleep in Kcna2 knockout mice. BMC Biol 5, 42
  57. Vyazovskiy, V. V., Ruijgrok, G., Deboer, T., and Tobler, I. (2006) Running wheel accessibility affects the regional electroencephalogram during sleep in mice. Cereb Cortex 16, 328-336
  58. Vyazovskiy, V. V., Kopp, C., Wigger, E., Jones, M. E., Simpson, E. R., and Tobler, I. (2006) Sleep and rest regulation in young and old oestrogen-deficient female mice. J Neuroendocrinol 18, 567-576
  59. Vyazovskiy, V. V., and Tobler, I. (2005) Theta activity in the waking EEG is a marker of sleep propensity in the rat. Brain Res 1050, 64-71
  60. Vyazovskiy, V. V., and Tobler, I. (2005) Regional differences in NREM sleep slow-wave activity in mice with congenital callosal dysgenesis. J Sleep Res 14, 299-304
  61. Vyazovskiy, V. V., Kopp, C., Bosch, G., and Tobler, I. (2005) The GABAA receptor agonist THIP alters the EEG in waking and sleep of mice. Neuropharmacology 48, 617-626
  62. Vyazovskiy, V. V., Welker, E., Fritschy, J. M., and Tobler, I. (2004) Regional pattern of metabolic activation is reflected in the sleep EEG after sleep deprivation combined with unilateral whisker stimulation in mice. Eur J Neurosci 20, 1363-1370
  63. Vyazovskiy, V. V., Achermann, P., Borbely, A. A., and Tobler, I. (2004) The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice. Arch Ital Biol 142, 511-523
  64. Vyazovskiy, V., Achermann, P., Borbely, A. A., and Tobler, I. (2004) Interhemispheric coherence of the sleep electroencephalogram in mice with congenital callosal dysgenesis. Neuroscience 124, 481-488
  65. Vyazovskiy, V. V., Deboer, T., Rudy, B., Lau, D., Borbely, A. A., and Tobler, I. (2002) Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2. Brain Res 947, 204-211
  66. Vyazovskiy, V. V., Borbely, A. A., and Tobler, I. (2002) Interhemispheric sleep EEG asymmetry in the rat is enhanced by sleep deprivation. J Neurophysiol 88, 2280-2286
  67. Vyazovskiy, V., Borbely, A. A., and Tobler, I. (2000) Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat. J Sleep Res 9, 367-371
  68. Deboer, T., Vyazovskiy, V. V., and Tobler, I. (2000) Long photoperiod restores the 24-h rhythm of sleep and EEG slow-wave activity in the Djungarian hamster (Phodopus sungorus). J Biol Rhythms 15, 429-436