Curriculum Vitae

Vladyslav Vyazovskiy, PhD (http://vvlab.org/)

•    EDUCATION

2004     PhD, University of Zurich, Zurich, Switzerland    
1997     MSc, University of Kharkov, Kharkov, Ukraine    
    
•    CURRENT POSITION(S)

2013 –  Senior Research Fellow, Associate Professor of Neuroscience
Department of Physiology, Anatomy and Genetics, University of Oxford
        
•    PREVIOUS POSITIONS

2012-2013    Lecturer in Sleep and Chronobiology, Department of Biochemistry and Physiology, University of Surrey, UK;
2011-2012    Associate Scientist, Department of Psychiatry, University of Wisconsin-Madison, Madison, USA;
2008-2011    Assistant Scientist, Department of Psychiatry, University of Wisconsin-Madison, Madison, USA;
2005-2008    Research Associate, Department of Psychiatry, University of Wisconsin-Madison, Madison, USA;

•    FELLOWSHIPS AND AWARDS

2016  Keynote speaker, 1st International Conference on Sleep Spindles, Budapest, Hungary;
2015  Keynote speaker, 12th Annual Symposium of Korean Sleep Research Society (KSSR);
2014  Travel Awardee for the 2014 American College of Neuropsychopharmacology meeting;
2013  Keynote speaker, XIV Brazilian Sleep Meeting, Rio de Janeiro, Brazil;
2013  “Year in Review”, Invited speaker, 25th Meeting of British Sleep Society, UK;
2011  “Notable Publication in Sleep”, Sleep Research Society, 2011;
2008  Sleep Research Society Young Investigator Award;
2005-2006  Two-years Research Fellowship, Swiss National Science Foundation;
2002  Travel Awardee for the 2002 FENS meeting, Paris

•    ORGANISATION OF SCIENTIFIC MEETINGS/SYMPOSIA

2014    “11 minutes of sleep: an open window on brain plasticity, cortical functions and consciousness”, Satellite Symposium, Italian Sleep Society bi-annual meeting, Pisa, Italy, November 5th, 2014 (symposium co-organiser).
2015    "Sleep, Brain State and Sensory processing", British Neuroscience Association festival, 2015, Edinburgh, UK. Speakers: K. Harris, A. Thiele, M Sanchez-Vives (symposium organiser)

•    MEMBERSHIPS IN SCIENTIFIC SOCIETIES

2001 –    Member, European Sleep Research Society
2012 –    Member, British Neuroscience Association
2005 –    Member, Sleep Research Society
2015-     Member, European Biological Rhythms Society

•    REVIEWER ACTIVITIES

Journals:
Science, Nature Communications, Nature Methods, Current Biology, Cerebral Cortex, Proceedings B is the Royal Society, The Journal of Neuroscience, The Journal of Neurophysiology, The European Journal of Neuroscience, Genes, Brain and Behaviour, Neuroscience, The Journal of Sleep Research, Sleep, Brain Research, Experimental Brain Research, Behavioural Brain Research, Current Topics in Medicinal Chemistry, Journal of Theoretical Biology, Neurogastroenterology and Motility, PLoS One, British Journal of Pharmacology and others.

Funding Bodies:
The Italian Ministry of Education, University and Research (MIUR), La Fondation Leenaards, Research Councils UK (NC3R, MRC), Austrian Science Fund, Wellcome Trust/DBT India Alliance, Swiss National Science Foundation.

•    EDITORIAL ACTIVITIES

Academic Editor at PLoS1, Consulting Editor at Dove Press (Journal of Nature and Science of Sleep), Associate Editor at Frontiers in Systems Neuroscience

•    CURRENT FUNDING / PROJECTS

1. BBSRC Industrial CASE studentship (together with Eli Lilly), 2013-2017 (primary supervisor).
2. MRC New Investigator Grant, 2013-2017 (principal investigator)
3. European Space Agency Ariadna Initiative, 2015-2016 (principal investigator)
4. FP7 Marie Curie Career Integration Grant, 2012-2016 (principal investigator)
5. The Royal Society Research Grant, 2013-2014
6. John Fell OUP Research Fund, University of Oxford, 2014-2015
7. Oxford-Brain@McGill-ZNZ Partnership in the Neurosciences Funding, 2014-2015

•    RESEARCH GROUP

1. Dr Tomoko Yamagata (postdoctoral researcher)
2. Dr S. Hasan (postdoctoral researcher)
3. Dr A. Ramkisoensing (postdoctoral researcher)
4. Nanyi Cui (DPhil student, co-supervised by Dr P. Oliver, 2014-2017)
5. Laura McKillop (DPhil student, co-supervised by Prof. Dame K. Davies, Dr K.A. Wafford, BBSRC, Eli Lilly, 2014-2017)
6. Mathilde Guillaumin (DTP BBSRC, co-supervised by Dr S. Peirson, 2015-2018)
7. Ross Purple (co-supervised by Dr K. Porcheret and K. Wulff, 2012-2016)
8. Minas Salib (co-supervised by Dr. T. Viney, 2015-2018)
9. Christopher Thomas (DTP BBSRC, co-supervised by Dr M. de Vos, 2016-2019)
10. Alberto Lazari (co-supervised by Prof. H. Johansen-Berg and Prof. D. Bannerman)
11. Cristina Blanco Duque (co-supervised by Prof. H. Johansen-Berg and Prof. D. Bannerman)

•    PUBLICATIONS
total 56, citations >2200, h-index 25 (Web of Science)

1.     Sela Y, Vyazovskiy VV, Cirelli C, Tononi G, Nir Y. Responses in Rat Core Auditory Cortex are Preserved during Sleep Spindle Oscillations. Sleep 2016;39(5):1069-82.
2.     Pilorz V, Tam SK, Hughes S, Pothecary CA, Jagannath A, Hankins MW, Bannerman DM, Lightman SL, Vyazovskiy VV, Nolan PM, Foster RG, Peirson SN. Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light. PLoS Biol 2016;14(6):e1002482.
3.     Fisher SP, Cui N, McKillop LM, Gemignani J, Bannerman DM, Oliver PL, Peirson SN, Vyazovskiy VV. Stereotypic wheel running decreases cortical activity in mice. Nat Comm 2016;in press.
4.     Boccio M, Fisher SP, Unal G, Ellender TJ, Vyazovskiy VV, Capogna M. Modulation of paracapsular nitric oxide synthase expressing neurons of the amygdala by sleep and serotonin. eNeuro 2016;in press.
5.     Vyazovskiy VV, Faraguna U. Sleep and synaptic homeostasis. Curr Top Behav Neurosci 2015;25:91-121.
6.     Vyazovskiy VV. Neuroscience. Mapping the birth of the sleep connectome. Science 2015;350(6263):909-10.
7.     Vyazovskiy VV. Sleep, recovery, and metaregulation: explaining the benefits of sleep. Nat Sci Sleep 2015;7:171-84.
8.     Nir Y, Vyazovskiy VV, Cirelli C, Banks MI, Tononi G. Auditory responses and stimulus-specific adaptation in rat auditory cortex are preserved across NREM and REM sleep. Cereb Cortex 2015;25(5):1362-78.
9.     Axelsson J, Vyazovskiy VV. Banking Sleep and Biological Sleep Need. Sleep 2015;38(12):1843-5.
10.    Abasolo D, Simons S, Morgado da Silva R, Tononi G, Vyazovskiy VV. Lempel-Ziv complexity of cortical activity during sleep and waking in rats. J Neurophysiol 2015;113(7):2742-52.
11.    Vyazovskiy VV, Foster RG. Sleep: a biological stimulus from our nearest celestial neighbor? Curr Biol 2014;24(12):R557-60.
12.    Vyazovskiy VV, Faraguna U. Sleep and synaptic homeostasis. Curr Top Behav Neurosci 2014;25:91-121.
13.    Vyazovskiy VV, Delogu A. NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness. Neuroscientist 2014;20(3):203-19.
14.    Vyazovskiy VV, Cui N, Rodriguez AV, Funk C, Cirelli C, Tononi G. The dynamics of cortical neuronal activity in the first minutes after spontaneous awakening in rats and mice. Sleep 2014;37(8):1337-47.
15.    Fisher SP, Vyazovskiy VV. Local sleep taking care of high-maintenance cortical circuits under sleep restriction. Sleep 2014;37(11):1727-30.
16.    Cui N, McKillop LE, Fisher SP, Oliver PL, Vyazovskiy VV. Long-term history and immediate preceding state affect EEG slow wave characteristics at NREM sleep onset in C57BL/6 mice. Arch Ital Biol 2014;152(2-3):156-68.
17.    Vyazovskiy VV, Olcese U, Cirelli C, Tononi G. Prolonged wakefulness alters neuronal responsiveness to local electrical stimulation of the neocortex in awake rats. J Sleep Res 2013;22(3):264-71.
18.    Vyazovskiy VV, Harris KD. Sleep and the single neuron: the role of global slow oscillations in individual cell rest. Nat Rev Neurosci 2013;14(6):443-51.
19.    Vyazovskiy VV. Cortical neuronal mechanisms of sleep homeostasis. Zh Vyssh Nerv Deiat Im I P Pavlova 2013;63(1):13-23.
20.    Vyazovskiy VV, Tobler I. The temporal structure of behaviour and sleep homeostasis. PLoS One 2012;7(12):e50677.
21.    Bellesi M, Vyazovskiy VV, Tononi G, Cirelli C, Conti F. Reduction of EEG theta power and changes in motor activity in rats treated with ceftriaxone. PLoS One 2012;7(3):e34139.
22.    Vyazovskiy VV, Olcese U, Hanlon EC, Nir Y, Cirelli C, Tononi G. Local sleep in awake rats. Nature 2011;472(7344):443-7.
23.    Vyazovskiy VV, Cirelli C, Tononi G. Electrophysiological correlates of sleep homeostasis in freely behaving rats. Prog Brain Res 2011;193:17-38.
24.    Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, Fried I, Tononi G. Regional slow waves and spindles in human sleep. Neuron 2011;70(1):153-69.
25.    Hanlon EC, Vyazovskiy VV, Faraguna U, Tononi G, Cirelli C. Synaptic potentiation and sleep need: clues from molecular and electrophysiological studies. Curr Top Med Chem 2011;11(19):2472-82.
26.    Leemburg S, Vyazovskiy VV, Olcese U, Bassetti CL, Tononi G, Cirelli C. Sleep homeostasis in the rat is preserved during chronic sleep restriction. Proc Natl Acad Sci U S A 2010;107(36):15939-44.
27.    Faraguna U, Nelson A, Vyazovskiy VV, Cirelli C, Tononi G. Unilateral cortical spreading depression affects sleep need and induces molecular and electrophysiological signs of synaptic potentiation in vivo. Cereb Cortex 2010;20(12):2939-47.
28.    Vyazovskiy VV, Tobler I, Cirelli C, Tononi G. Author's reply to "cerebral metabolism and sleep homeostasis: a comment on Vyazovskiy et al.". Brain Res Bull 2009;80(6):443-5.
29.    Vyazovskiy VV, Olcese U, Lazimy YM, Faraguna U, Esser SK, Williams JC, Cirelli C, Tononi G. Cortical firing and sleep homeostasis. Neuron 2009;63(6):865-78.
30.    Vyazovskiy VV, Faraguna U, Cirelli C, Tononi G. Triggering slow waves during NREM sleep in the rat by intracortical electrical stimulation: effects of sleep/wake history and background activity. J Neurophysiol 2009;101(4):1921-31.
31.    Hanlon EC, Faraguna U, Vyazovskiy VV, Tononi G, Cirelli C. Effects of skilled training on sleep slow wave activity and cortical gene expression in the rat. Sleep 2009;32(6):719-29.
32.    Dash MB, Douglas CL, Vyazovskiy VV, Cirelli C, Tononi G. Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. J Neurosci 2009;29(3):620-9.
33.    Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I. Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience 2008;154(2):595-605.
34.    Vyazovskiy VV, Tobler I. Handedness leads to interhemispheric EEG asymmetry during sleep in the rat. J Neurophysiol 2008;99(2):969-75.
35.    Vyazovskiy VV, Cirelli C, Tononi G, Tobler I. Cortical metabolic rates as measured by 2-deoxyglucose-uptake are increased after waking and decreased after sleep in mice. Brain Res Bull 2008;75(5):591-7.
36.    Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G. Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 2008;11(2):200-8.
37.    Jones SG, Vyazovskiy VV, Cirelli C, Tononi G, Benca RM. Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii). BMC Neurosci 2008;9:47.
38.    Faraguna U, Vyazovskiy VV, Nelson AB, Tononi G, Cirelli C. A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci 2008;28(15):4088-95.
39.    Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I. The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. Eur J Neurosci 2007;25(6):1893-9.
40.    Vyazovskiy VV, Tobler I, Winsky-Sommerer R. Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization. Neuroscience 2007;147(3):833-41.
41.    Vyazovskiy VV, Riedner BA, Cirelli C, Tononi G. Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat. Sleep 2007;30(12):1631-42.
42.    Vyazovskiy VV, Achermann P, Tobler I. Sleep homeostasis in the rat in the light and dark period. Brain Res Bull 2007;74(1-3):37-44.
43.    Riedner BA, Vyazovskiy VV, Huber R, Massimini M, Esser S, Murphy M, Tononi G. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 2007;30(12):1643-57.
44.    Douglas CL, Vyazovskiy V, Southard T, Chiu SY, Messing A, Tononi G, Cirelli C. Sleep in Kcna2 knockout mice. BMC Biol 2007;5:42.
45.    Vyazovskiy VV, Ruijgrok G, Deboer T, Tobler I. Running wheel accessibility affects the regional electroencephalogram during sleep in mice. Cereb Cortex 2006;16(3):328-36.
46.    Vyazovskiy VV, Kopp C, Wigger E, Jones ME, Simpson ER, Tobler I. Sleep and rest regulation in young and old oestrogen-deficient female mice. J Neuroendocrinol 2006;18(8):567-76.
47.    Vyazovskiy VV, Tobler I. Theta activity in the waking EEG is a marker of sleep propensity in the rat. Brain Res 2005;1050(1-2):64-71.
48.    Vyazovskiy VV, Tobler I. Regional differences in NREM sleep slow-wave activity in mice with congenital callosal dysgenesis. J Sleep Res 2005;14(3):299-304.
49.    Vyazovskiy VV, Kopp C, Bosch G, Tobler I. The GABAA receptor agonist THIP alters the EEG in waking and sleep of mice. Neuropharmacology 2005;48(5):617-26.
50.    Vyazovskiy VV, Welker E, Fritschy JM, Tobler I. Regional pattern of metabolic activation is reflected in the sleep EEG after sleep deprivation combined with unilateral whisker stimulation in mice. Eur J Neurosci 2004;20(5):1363-70.
51.    Vyazovskiy VV, Achermann P, Borbely AA, Tobler I. The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice. Arch Ital Biol 2004;142(4):511-23.
52.    Vyazovskiy V, Achermann P, Borbely AA, Tobler I. Interhemispheric coherence of the sleep electroencephalogram in mice with congenital callosal dysgenesis. Neuroscience 2004;124(2):481-8.
53.    Vyazovskiy VV, Deboer T, Rudy B, Lau D, Borbely AA, Tobler I. Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2. Brain Res 2002;947(2):204-11.
54.    Vyazovskiy VV, Borbely AA, Tobler I. Interhemispheric sleep EEG asymmetry in the rat is enhanced by sleep deprivation. J Neurophysiol 2002;88(5):2280-6.
55.    Vyazovskiy V, Borbely AA, Tobler I. Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat. J Sleep Res 2000;9(4):367-71.
56.    Deboer T, Vyazovskiy VV, Tobler I. Long photoperiod restores the 24-h rhythm of sleep and EEG slow-wave activity in the Djungarian hamster (Phodopus sungorus). J Biol Rhythms 2000;15(5):429-36.

•     BOOK CHAPTER

Vyazovskiy V.V., Olcese U., Tononi G. " Investigating Sleep Homeostasis with Extracellular Recording of Multiunit Activity from the Neocortex in Freely Behaving Rats" In Fellin, T. and Halassa, M. (Eds), Neuronal Networks Analysis, Concepts and Experimental Approaches, Neuromethods Series, Vol. 67, Springer (2012).

•    TEACHING

2014-      2nd year Medical Sciences / Biomedical Sciences; FHS Cell & Systems Biology, Medical Sciences & Neuroscience (lecturer);
2015-2016  Course ‘Cognition and Culture’, Human Sciences (lecturer);
2016-      Module "Genes, Circuits and Behaviour", MSc in Neuroscience (Module co-organiser, lecturer);
2016-      The Oxford Online Programme in Sleep Medicine (Module lead, lecturer);
2015-2016- ‘Sleep and Circadian Neuroscience’ Summer School, University of Oxford (faculty);
2016-      Oxford Doctoral Training Centre, teaching;                            
2017-      Biomedical Sciences Year 2 (FHS Part I): Sleep and Circadian Neuroscience Option (option organiser, lecturer, tutor)
2014-      DPhil transfer/ status confirmation examinations, DPhil vivas, essays marking